Fumaric Acid → 1-[3-(4-Fluorophenoxy)-1-azetidinylcarbonyl]-4-(phenylmethyl)piperazine fumarate

HRID 1032161

반응식

HRID 1032161 반응식
[F:1][C:2]1[CH:27]=[CH:26][C:5]([O:6][CH:7]2[CH2:10][N:9]([C:11]([N:13]3[CH2:18][CH2:17][N:16]([CH2:19][C:20]4[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=4)[CH2:15][CH2:14]3)=[O:12])[CH2:8]2)=[CH:4][CH:3]=1.[C:28]([OH:35])(=[O:34])/[CH:29]=[CH:30]/[C:31]([OH:33])=[O:32]>C(O)(C)C>[C:28]([OH:35])(=[O:34])/[CH:29]=[CH:30]/[C:31]([OH:33])=[O:32].[F:1][C:2]1[CH:3]=[CH:4][C:5]([O:6][CH:7]2[CH2:8][N:9]([C:11]([N:13]3[CH2:14][CH2:15][N:16]([CH2:19][C:20]4[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=4)[CH2:17][CH2:18]3)=[O:12])[CH2:10]2)=[CH:26][CH:27]=1

참가 물질

4

반응물 2

HCID 444972Fumaric AcidHCID 150534051-[3-(4-Fluorophenoxy)-1-azetidinylcarbonyl]-4-(phenylmethyl)piperazine

생성물 1

HCID 197995931-[3-(4-Fluorophenoxy)-1-azetidinylcarbonyl]-4-(phenylmethyl)piperazine fumarate수율 91.3%

시약·촉매·용매 1

HCID 3776Isopropanol용매2회

실험 절차

A 2.5 g portion of 1-[3-(4-fluorophenoxy)-1-azetidinylcarbonyl]-4-(phenylmethyl)piperazine was dissolved in isopropanol and treated with 0.8 g of fumaric acid dissolved in 2.5 ml of hot isopropanol. Upon cooling, the precipitate was collected by filtration, yielding 3 g (91.3%) of fine white crystals, m.p. 183°-184° C.

후처리

  1. temperatureUpon cooling
  2. filtrationthe precipitate was collected by filtration

출처 및 근거

ORD 기록
ord-5b7ff3f8c80042018d16a6293997fd92
출처 데이터셋
uspto-grants-1990_09
특허 번호
US04956359

연결된 노트

불러오는 중…