Acetyl chloride → N-Dodecylacetamide

HRID 1032282노트

반응식

HRID 1032282 반응식
[CH2:1]([NH2:13])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12].C(N(CC)CC)C.[C:21](Cl)(=[O:23])[CH3:22]>ClCCl>[C:21]([NH:13][CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12])(=[O:23])[CH3:22]

참가 물질

5

반응물 3

HCID 6367Acetyl chlorideHCID 8471TriethylamineHCID 13583Dodecylamine

생성물 1

HCID 19764N-Dodecylacetamide

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A mixture of 1-dodecylamine (1.049 g, 5.59 mmol), triethylamine (0.86 ml, 6.15 mmol) and acetyl chloride (0.44 ml, 6.15 mmol) in dichloromethane (10 ml) was stirred at room temperature for 3h. The mixture was quenched with water and the organic phase was separated. Evaporation of the dried (magnesium sulfate) organic phase gave a solid, which was recrystallized from hexane to give the titled amide.

후처리

  1. customThe mixture was quenched with water
  2. customthe organic phase was separated
  3. customEvaporation of the
  4. dry with materialdried (magnesium sulfate) organic phase
  5. customgave a solid, which
  6. customwas recrystallized from hexane

출처 및 근거

ORD 기록
ord-1c95227a49a044f4a215eed2c8de5bdb
출처 데이터셋
uspto-grants-1990_09
특허 번호
US04957917

반응 노트

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