4-(Chloromethyl)-2,2-dimethyl-1,3-dioxolane → 4-(Azidomethyl)-2,2-dimethyl-1,3-dioxolane

HRID 1032360

반응식

HRID 1032360 반응식
[CH3:1][C:2]1([CH3:9])[O:6][CH:5]([CH2:7]Cl)[CH2:4][O:3]1.[N-:10]=[N+:11]=[N-:12].[Na+]>CN(C=O)C>[CH3:1][C:2]1([CH3:9])[O:6][CH:5]([CH2:7][N:10]=[N+:11]=[N-:12])[CH2:4][O:3]1

참가 물질

4

반응물 2

HCID 203744-(Chloromethyl)-2,2-dimethyl-1,3-dioxolaneHCID 33557Sodium Azide

생성물 1

HCID 115356024-(Azidomethyl)-2,2-dimethyl-1,3-dioxolane

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

15.05 g. of 2,2-dimethyl-4-chloromethyl-1,3-dioxolane is dissolved in 100 ml. DMF and 6.5 g. of NaN3 are added. The mixture is stirred at 50° overnight, cooled to room temperature, diluted with 300 ml. C6H6 and washed 5 times with water. The organic phase is dried and evaporated under reduced pressure to give 2,2-dimethyl-4-azidomethyl-1,3-dioxolane.

후처리

  1. additiondiluted with 300 ml
  2. washC6H6 and washed 5 times with water
  3. customThe organic phase is dried
  4. customevaporated under reduced pressure

출처 및 근거

ORD 기록
ord-322a5de2c9ca4d35ab95d469a423d030
출처 데이터셋
uspto-grants-1990_09
특허 번호
US04957912

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