Hydrochloric Acid → 5,6-Dimethoxy-2-methyl-2,3-dihydro-1H-isoindole--hydrogen chloride (1/1)

HRID 1032487노트

반응식

HRID 1032487 반응식
[ClH:1].[CH2:2]([N+:9]1(C)[CH2:17][C:16]2[C:11](=[CH:12][C:13]([O:20][CH3:21])=[C:14]([O:18][CH3:19])[CH:15]=2)[CH2:10]1)C1C=CC=CC=1.Cl.[H][H]>CO.[C].[Pd]>[ClH:1].[CH3:19][O:18][C:14]1[CH:15]=[C:16]2[C:11](=[CH:12][C:13]=1[O:20][CH3:21])[CH2:10][N:9]([CH3:2])[CH2:17]2

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 22166076HCID 22166076, 화합물HCID 178418361HCID 178418361, 화합물

생성물 1

HCID 200743475,6-Dimethoxy-2-methyl-2,3-dihydro-1H-isoindole--hydrogen chloride (1/1)

시약·촉매·용매 2

HCID 178418390HCID 178418390, 화합물촉매HCID 887Methanol용매

실험 절차

1.0 g (3.12 mmol) of N-benzyl-5,6-dimethoxy-N-methylisoindolinium hydrochloride was dissolved in 20 ml of methanol, and 0.5 ml of 6N hydrochloric acid and 100 mg of a 10% palladium carbon catalyst were added thereto. The catalytic reduction was conducted at room temperature for 5 hours in a hydrogen gas stream. The catalyst was filtered off, and the solvent was distilled off under reduced pressure. The crystal residue was washed with 10 ml of acetone to obtain 650 mg of the above identified compound.

후처리

  1. filtrationThe catalyst was filtered off
  2. distillationthe solvent was distilled off under reduced pressure
  3. washThe crystal residue was washed with 10 ml of acetone
  4. customto obtain 650 mg of the

출처 및 근거

ORD 기록
ord-89a57bb2a0734bfc85b7ae90b37eb582
출처 데이터셋
uspto-grants-1990_09
특허 번호
US04958029

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