HCID 13629298, 화합물 → 2-(3-Amino-4-benzyloxyphenyl)acetic acid dipropylamide

HRID 1032509노트

반응식

HRID 1032509 반응식
[CH2:1]([N:4]([CH2:25][CH2:26][CH3:27])[C:5](=[O:24])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[C:9]([N+:21]([O-])=O)[CH:8]=1)[CH2:2][CH3:3].[H][H]>[Ni].CO>[CH2:25]([N:4]([CH2:1][CH2:2][CH3:3])[C:5](=[O:24])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[C:9]([NH2:21])[CH:8]=1)[CH2:26][CH3:27]

참가 물질

5

반응물 2

HCID 13629298HCID 13629298, 화합물HCID 178418361HCID 178418361, 화합물

생성물 1

HCID 136292992-(3-Amino-4-benzyloxyphenyl)acetic acid dipropylamide수율 73.7%

시약·촉매·용매 2

HCID 935Nickel촉매HCID 887Methanol용매

실험 절차

In the presence of Raney nickel, 36.0 g of 2-(4-benzyloxy-3-nitrophenyl)acetic acid dipropylamide is hydrogenated in 600 ml of methanol until 6.7 l of hydrogen has been absorbed, which takes about 4.5 hours. The crude product obtained after removing the catalyst by filtration and after evaporation is chromatographed on silica gel with cyclohexane/ethyl acetate (1:1), thus obtaining 24.4 g of pure 2-(3-amino-4-benzyloxyphenyl)acetic acid dipropylamide as an oil.

후처리

  1. customhas been absorbed
  2. customThe crude product obtained
  3. customafter removing the catalyst
  4. filtrationby filtration
  5. customafter evaporation
  6. customis chromatographed on silica gel with cyclohexane/ethyl acetate (1:1)

출처 및 근거

ORD 기록
ord-738ee511f8344515839a0616d119ba45
출처 데이터셋
uspto-grants-1990_09
특허 번호
US04958026

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