Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-(7-nitro-1H-indazol-4-yl)acetonitrile → 2-(7-amino-1H-indazol-4-yl)acetonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-(7-nitro-1H-indazol-4-yl)acetonitrile | HCID 13629308 | — |
| 촉매 | Nickel | HCID 935 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 2-(7-amino-1H-indazol-4-yl)acetonitrile | HCID 19354434 | 87.8% |
반응 단계
20.2 g of 2-(7-nitro-1H-indazol-4-yl)-acetonitrile in 750 ml of tetrahydrofuran is hydrogenated in the presence of 20.0 g of Raney nickel. The product is recrystallized from tetrahydrofuran/hexane, yielding 15.1 g of 2-(7-amino-1H-indazol-4-yl)acetonitrile, mp 164°-165° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04958026 |
| 출처 데이터셋 | uspto-grants-1990_09 |
| ORD ID | ord-eb4a0d8baa674734875fca2f76128da7 |
| 출처 메모 | uspto-grants-1990_09 |