Thiourea → HCID 178432392, 화합물
반응식
C([O:4][CH2:5][C:6]1[CH:11]=[C:10](Cl)[N:9]2[N:13]=[C:14]([CH3:16])[N:15]=[C:8]2[N:7]=1)(=O)C.NC(N)=[S:19]>C(O)C>[OH:4][CH2:5][C:6]1[CH:11]=[C:10]([SH:19])[N:9]2[N:13]=[C:14]([CH3:16])[N:15]=[C:8]2[N:7]=1참가 물질
4
실험 절차
In 600 ml of ethanol was dissolved 31 g of 5-acetoxymethyl7-chloro-2-methyl-s-triazolo[1,5-a]pyrimidine, and 29.5 g of thiourea was added thereto and the mixture was refluxed for 10 minutes. The reaction mixture was ice-cooled and resulting precipitated crystal was collected by filtration. The crystal was dissolved in 600 ml of a 5 % potassium hydroxide and the mixture was stirred for 30 minutes, ice-cooled and adjusted to pH 2 with 2N hydrochloric acid. Precipitated crystal was collected by filtration, washed with water and dried to obtain 16.33 g of the title compound.
후처리
- additionwas added
- temperaturethe mixture was refluxed for 10 minutes
- temperaturecooled
- customresulting
- customprecipitated crystal
- filtrationwas collected by filtration
- dissolutionThe crystal was dissolved in 600 ml of a 5 % potassium hydroxide
- temperatureice-cooled
- customPrecipitated crystal
- filtrationwas collected by filtration
- washwashed with water
- customdried
출처 및 근거
- ORD 기록
- ord-1fec2fd65e8c43b4b11c14bcfaa310d6
- 출처 데이터셋
- uspto-grants-1990_09
- 특허 번호
- US04958019
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