2-Nitroacetamide → 2(1H)-Pyridinone, 5-ethyl-6-methyl-3-nitro-

HRID 1032988

반응식

HRID 1032988 반응식
[CH2:1]([CH:3]([C:6](=O)[CH3:7])[CH:4]=O)[CH3:2].[Na].[N+:10]([CH2:13][C:14]([NH2:16])=[O:15])([O-:12])=[O:11].C([O-])(=O)C.[NH2+]1CCCCC1>O>[CH2:6]([C:3]1[CH:4]=[C:13]([N+:10]([O-:12])=[O:11])[C:14](=[O:15])[NH:16][C:1]=1[CH3:2])[CH3:7]

참가 물질

6

반응물 4

HCID 2792562-NitroacetamideHCID 3014295Piperidinium acetateHCID 5360545SodiumHCID 152284102-Ethyl-3-oxobutanal

생성물 1

HCID 103523142(1H)-Pyridinone, 5-ethyl-6-methyl-3-nitro-수율 80%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture of 2-ethyl-3-oxobutanal, sodium salt (7.5 g, 55 mmol), nitroacetamide (6.6 g, 63 mmol), aqueous piperidinium acetate (4.4 mL) [prepared from glacial acetic acid (42 mL), water (100 mL) and piperidine (72 mL)] in water (45 mL) was stirred at room temperature for 22 hours. The yellow precipitate was collected by filtration and air dried to yield 8.0 g (80%) of 5-ethyl-6-methyl-3-nitro-2-(1H)-pyridinone.

후처리

  1. filtrationThe yellow precipitate was collected by filtration and air
  2. customdried

출처 및 근거

ORD 기록
ord-e763b5b7379b4dc9a4bb699f2714a2a5
출처 데이터셋
uspto-grants-1994_05
특허 번호
US05308854

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