2-Nitroacetamide → 2(1H)-Pyridinone, 5-ethyl-6-methyl-3-nitro-
반응식
[CH2:1]([CH:3]([C:6](=O)[CH3:7])[CH:4]=O)[CH3:2].[Na].[N+:10]([CH2:13][C:14]([NH2:16])=[O:15])([O-:12])=[O:11].C([O-])(=O)C.[NH2+]1CCCCC1>O>[CH2:6]([C:3]1[CH:4]=[C:13]([N+:10]([O-:12])=[O:11])[C:14](=[O:15])[NH:16][C:1]=1[CH3:2])[CH3:7]참가 물질
6
실험 절차
A mixture of 2-ethyl-3-oxobutanal, sodium salt (7.5 g, 55 mmol), nitroacetamide (6.6 g, 63 mmol), aqueous piperidinium acetate (4.4 mL) [prepared from glacial acetic acid (42 mL), water (100 mL) and piperidine (72 mL)] in water (45 mL) was stirred at room temperature for 22 hours. The yellow precipitate was collected by filtration and air dried to yield 8.0 g (80%) of 5-ethyl-6-methyl-3-nitro-2-(1H)-pyridinone.
후처리
- filtrationThe yellow precipitate was collected by filtration and air
- customdried
출처 및 근거
- ORD 기록
- ord-e763b5b7379b4dc9a4bb699f2714a2a5
- 출처 데이터셋
- uspto-grants-1994_05
- 특허 번호
- US05308854
반응 노트
불러오는 중…