2-Bromomethylnaphthalene → HCID 936893, 화합물

HRID 1033002노트

반응식

HRID 1033002 반응식
N[C:2]1[C:3](SC(C)(C)C)=[N:4][C:5](C)=[C:6](CC)[CH:7]=1.BrC[C:18]1[CH:27]=[CH:26][C:25]2[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=2)[CH:19]=1.[CH:28]([N:31](C(C)C)CC)(C)C>C(#N)C>[C:21]1([CH2:28][NH:31][C:3]2[CH:2]=[CH:7][CH:6]=[CH:5][N:4]=2)[C:20]2[C:25](=[CH:26][CH:27]=[CH:18][CH:19]=2)[CH:24]=[CH:23][CH:22]=1

참가 물질

5

반응물 3

HCID 703202-BromomethylnaphthaleneHCID 81531DiisopropylethylamineHCID 10105052HCID 10105052, 화합물

생성물 1

HCID 936893HCID 936893, 화합물수율 62.4%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

A mixture of 3-amino-2-tert-butylthio-5-ethyl-6-methylpyridine (0.15 g, 0.67 mmol), 2-bromomethyl-napthalene (0.15 g, 0.67 mmol), diisopropylethylamine (86 mg, 0.67 mmol) in acetonitrile (5 mL) was refluxed under an atmosphere of nitrogen for 16 hours. The resultant mixture was concentrated under reduced pressure (15 (torr). The residue was subjected to column chromatography on silica gel (50, elution with 1% methanol in chloroform). Collection and concentration of appropriate fractions provided 98 mg (40%) of the napthylmethylaminopyridine.

후처리

  1. temperaturewas refluxed under an atmosphere of nitrogen for 16 hours
  2. concentrationThe resultant mixture was concentrated under reduced pressure (15 (torr)
  3. customCollection and concentration of appropriate fractions

출처 및 근거

ORD 기록
ord-8809eb84f1ad4137842a7d6249b0298f
출처 데이터셋
uspto-grants-1994_05
특허 번호
US05308854

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