2-Methoxy-3-cyano-5-ethyl-6-methylpyridine → 2-Methoxy-3-(aminomethyl)-5-ethyl-6-methylpyridine

HRID 1033010노트

반응식

HRID 1033010 반응식
[CH3:1][O:2][C:3]1[C:8]([C:9]#[N:10])=[CH:7][C:6]([CH2:11][CH3:12])=[C:5]([CH3:13])[N:4]=1>CO.Cl.[Pd]>[CH3:1][O:2][C:3]1[C:8]([CH2:9][NH2:10])=[CH:7][C:6]([CH2:11][CH3:12])=[C:5]([CH3:13])[N:4]=1

참가 물질

5

반응물 1

HCID 104422282-Methoxy-3-cyano-5-ethyl-6-methylpyridine

생성물 1

HCID 103299382-Methoxy-3-(aminomethyl)-5-ethyl-6-methylpyridine수율 89.1%

시약·촉매·용매 3

HCID 23938Palladium촉매HCID 313Hydrochloric Acid용매HCID 887Methanol용매

실험 절차

A solution of 2-methoxy-3-cyano-5-ethyl-6-methylpyridine (344 mg, 1.95 mmol) in methanol (8 mL) and 4.9M methanolic HCl (5 mL) containing 5% palladium on carbon (100 mg) was hydrogenated at atmospheric pressure for 10-20 hours. The catalyst was filtered off and the solvent evaporated. This residue was made basic with sodium hydroxide and the product was extracted into methylene chloride, dried (Na2SO4), filtered and evaporated to give 313 mg (89% yield) of oily product.

후처리

  1. filtrationThe catalyst was filtered off
  2. customthe solvent evaporated
  3. extractionthe product was extracted into methylene chloride
  4. dry with materialdried (Na2SO4)
  5. filtrationfiltered
  6. customevaporated

출처 및 근거

ORD 기록
ord-6a900438c31649d6a09702299752c5b5
출처 데이터셋
uspto-grants-1994_05
특허 번호
US05308854

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