Nitromethane → 2-Methoxy-3-(2-nitroethenyl)-5-ethyl-6-methylpyridine
반응식
[CH3:1][O:2][C:3]1[N:10]=[C:9]([CH3:11])[C:8]([CH2:12][CH3:13])=[CH:7][C:4]=1[CH:5]=O.[N+:14]([CH3:17])([O-:16])=[O:15].Cl.CN.[OH-].[Na+]>C(O)C.CO>[CH3:1][O:2][C:3]1[C:4]([CH:5]=[CH:17][N+:14]([O-:16])=[O:15])=[CH:7][C:8]([CH2:12][CH3:13])=[C:9]([CH3:11])[N:10]=1참가 물질
7
실험 절차
A mixture of 2-methoxy-5-ethyl-6-methylnicotinaldehyde (2.25 g, 12.6 mmol), nitromethane (1.9 g, 31.1 mmol), monomethylamine hydrochloride (69 mg) and sodium hydroxide (20 mg) in absolute ethanol (1.3 mL) was stirred at ambient temperature for three days. This mixture was diluted with methanol and the precipitated yellow crystalline product was collected by filtration to yield 2.39 g (86%), m.p. 105°-107° C.
후처리
- filtrationthe precipitated yellow crystalline product was collected by filtration
- customto yield 2.39 g (86%), m.p. 105°-107° C.
출처 및 근거
- ORD 기록
- ord-82781bfacc6b4987961c3f7bbaf07d2a
- 출처 데이터셋
- uspto-grants-1994_05
- 특허 번호
- US05308854
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