Diethyl Ether → 2-ethoxycarbonyl-5-methyl-2,3-dihydro-1H-pyrrolo[3,4-c]pyridinium iodide

HRID 1033748노트

반응식

HRID 1033748 반응식
[CH2:1]1[C:9]2[CH:8]=[CH:7][N:6]=[CH:5][C:4]=2[CH2:3][N:2]1[C:10]([O:12][CH2:13][CH3:14])=[O:11].C[I:16].[CH2:17](OCC)C>C(#N)C>[I-:16].[CH2:13]([O:12][C:10]([NH+:2]1[CH2:1][C:9]2[CH:8]=[CH:7][N:6]([CH3:17])[CH2:5][C:4]=2[CH2:3]1)=[O:11])[CH3:14]

참가 물질

5

반응물 3

HCID 3283Diethyl EtherHCID 6328Methyl iodideHCID 18953633ethyl 1H-pyrrolo[3,4-c]pyridine-2(3H)-carboxylate

생성물 1

HCID 678240962-ethoxycarbonyl-5-methyl-2,3-dihydro-1H-pyrrolo[3,4-c]pyridinium iodide

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

9.6 g (50 mmol) of ethyl 2,3-dihydro-1H-pyrrolo-[3,4-c]pyridine-2-carboxylate and 6.3 ml (100 mmol) of methyl iodide are refluxed for 15 hours in 50 ml of acetonitrile. The batch is poured into diethyl ether, and the salt which has precipitated is filtered off with suction and dried in the air.

후처리

  1. customthe salt which has precipitated
  2. filtrationis filtered off with suction
  3. customdried in the air

출처 및 근거

ORD 기록
ord-59124bde501248bdb147f9bb83755fba
출처 데이터셋
uspto-grants-1994_05
특허 번호
US05312823

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