Water → 1-Chloro-4-(4-nitrophenoxy)benzene

HRID 1033761

반응식

HRID 1033761 반응식
F[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][CH:3]=1.[Cl:11][C:12]1[CH:17]=CC=[CH:14][C:13]=1O.O.C([O:23][CH2:24][CH3:25])(=O)C>CS(C)=O>[Cl:11][C:12]1[CH:17]=[CH:25][C:24]([O:23][C:2]2[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][CH:3]=2)=[CH:14][CH:13]=1

참가 물질

6

반응물 4

HCID 962WaterHCID 72452-ChlorophenolHCID 8857Ethyl AcetateHCID 9590p-Fluoronitrobenzene

생성물 1

HCID 157861-Chloro-4-(4-nitrophenoxy)benzene수율 98%

시약·촉매·용매 1

HCID 679Dimethyl Sulfoxide용매2회

실험 절차

A solution of 10.5 g (75.0 mmole) of 1-fluoro-4-nitrobenzene in 100 ml of dimethylsulfoxide and 9.64 g (75 mmole) of chlorophenol in 100 ml of DMSO was heated to 70° C. and maintained at this temperature for 4 hours. After allowing to cool to room temperature, 250 ml of water and then 250 ml of ethyl acetate were added slowly. The layers were separated and the organic layer was washed with 5×b 250 ml of water and 100 ml of sodium chloride, orange solid. Flash chromatography (CH2Cl2 eluent) yielded 18.34 g (98.0%) of the desired product as a yellow-orange solid.

후처리

  1. temperaturemaintained at this temperature for 4 hours
  2. customThe layers were separated
  3. washthe organic layer was washed with 5×b 250 ml of water and 100 ml of sodium chloride, orange solid

출처 및 근거

ORD 기록
ord-295d2ea3e874498c9713077d12bbb6e3
출처 데이터셋
uspto-grants-1994_05
특허 번호
US05312830

연결된 노트

불러오는 중…