Trimethylsilyl cyanide → 2-Hydroxy-2-(4-isobutylphenyl)acetonitrile
반응식
[CH2:1]([C:5]1[CH:12]=[CH:11][C:8]([CH:9]=[O:10])=[CH:7][CH:6]=1)[CH:2]([CH3:4])[CH3:3].C[Si]([C:17]#[N:18])(C)C>[I-].[Zn+2].[I-]>[OH:10][CH:9]([C:8]1[CH:7]=[CH:6][C:5]([CH2:1][CH:2]([CH3:4])[CH3:3])=[CH:12][CH:11]=1)[C:17]#[N:18]참가 물질
4
실험 절차
Zinc iodide (0.21 g) was added to a mixture of 4-isobutylbenzaldehyde (6.5 g) and trimethylsilylcyanide (5.0 g). The mixture was stirred at room temperature for 30 minutes and partitioned between ethyl acetate and 7% hydrochloric acid. The organic layer was washed with 7% hydrochloric acid and water and dried over magnesium sulfate. The solvent was removed in vacuo to give 2-hydroxy-2-(4-isobutylphenyl)acetonitrile as a yellow oil (8.15 g).
후처리
- custompartitioned between ethyl acetate and 7% hydrochloric acid
- washThe organic layer was washed with 7% hydrochloric acid and water
- dry with materialdried over magnesium sulfate
- customThe solvent was removed in vacuo
출처 및 근거
- ORD 기록
- ord-b79e71160be541bd93087455ed11cdf3
- 출처 데이터셋
- uspto-grants-1994_05
- 특허 번호
- US05312829
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