Imidazole → 5-[[(1,1-Dimethylethyl)diphenylsilyl]oxy]-2-methylpyridine

HRID 1034297노트

반응식

HRID 1034297 반응식
[OH:1][C:2]1[CH:3]=[CH:4][C:5]([CH3:8])=[N:6][CH:7]=1.N1C=CN=C1.[Si:14](Cl)([C:27]([CH3:30])([CH3:29])[CH3:28])([C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>C(Cl)Cl>[Si:14]([O:1][C:2]1[CH:3]=[CH:4][C:5]([CH3:8])=[N:6][CH:7]=1)([C:27]([CH3:30])([CH3:29])[CH3:28])([C:21]1[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=1)[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

참가 물질

5

반응물 3

HCID 795ImidazoleHCID 142752-Methyl-5-hydroxypyridineHCID 94078tert-Butyldiphenylchlorosilane

생성물 1

HCID 190237195-[[(1,1-Dimethylethyl)diphenylsilyl]oxy]-2-methylpyridine

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A solution of 10.9 g 5-hydroxypicoline, 8.85 g imidazole, and 29.9 mL t-butyldiphenylsilylchloride in 500 mL of CH2Cl2 was stirred for 4 days at 25° C. The mixture was washed with H2O, brine, dried over MgSO4, and concentrated under vacuum. The crude product was purified by silica gel chromatography (EtOAc/Hexane 10:90) to afford the pure title compound as an oil.

후처리

  1. washThe mixture was washed with H2O, brine
  2. dry with materialdried over MgSO4
  3. concentrationconcentrated under vacuum
  4. customThe crude product was purified by silica gel chromatography (EtOAc/Hexane 10:90)

출처 및 근거

ORD 기록
ord-87d91a8143584965893a993069350b98
출처 데이터셋
uspto-grants-1994_05
특허 번호
US05314900

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