Hydrochloric Acid → 4-Amino-3-(3,4-dichlorophenyl)-1-butanol

HRID 1034470

반응식

HRID 1034470 반응식
Cl.O1CCCCC1[O:8][CH2:9][CH2:10][CH:11]([C:14]1[CH:19]=[CH:18][C:17]([Cl:20])=[C:16]([Cl:21])[CH:15]=1)[CH2:12][NH2:13]>CCOCC.CO>[NH2:13][CH2:12][CH:11]([C:14]1[CH:19]=[CH:18][C:17]([Cl:20])=[C:16]([Cl:21])[CH:15]=1)[CH2:10][CH2:9][OH:8]

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 156708082-(3-(3,4-Dichlorophenyl)-4-aminobutyl)oxytetrahydropyran

생성물 1

HCID 97946634-Amino-3-(3,4-dichlorophenyl)-1-butanol

시약·촉매·용매 2

HCID 887Methanol용매HCID 3283Diethyl Ether용매

실험 절차

150 ml of a saturated solution of hydrogen chloride in ether are added to a solution of 149 g of 4-(tetrahydropyran-2-yloxy)-2-(3,4-dichlorophenyl)-1-aminobutane in 700 ml of methanol. The mixture is stirred for 1/2 hour at room temperature and concentrated under vacuum and the residue is taken up in 500 ml of water and washed with ether. The aqueous phase is rendered alkaline with a solution of sodium hydroxide and extracted twice with methylene chloride. The organic phases are dried over MgSO4, filtered and concentrated under vacuum. The residue is taken up in 400 ml of isopropyl ether and the mixture is stirred for one hour at room temperature. The precipitate is filtered off and washed with ether.

후처리

  1. concentrationconcentrated under vacuum
  2. washwashed with ether
  3. extractionextracted twice with methylene chloride
  4. dry with materialThe organic phases are dried over MgSO4
  5. filtrationfiltered
  6. concentrationconcentrated under vacuum
  7. stirringthe mixture is stirred for one hour at room temperature
  8. filtrationThe precipitate is filtered off
  9. washwashed with ether

출처 및 근거

ORD 기록
ord-a9aef8f98ac944b3ae5a4d65aedb6e44
출처 데이터셋
uspto-grants-1994_05
특허 번호
US05317020

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