홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

1-Methylpiperazine → 1-(4-(Azetidin-3-yloxy)-2-chlorobenzyl)-4-methylpiperazine

HRID 1035212
노트
인쇄 미리보기

반응식

HRID 1035212 반응식
[CH3:1][N:2]([CH2:4][C:5]1[CH:22]=[CH:21][C:8]([O:9][CH:10]2[CH2:13][N:12](C(OC(C)(C)C)=O)[CH2:11]2)=[CH:7][C:6]=1C)[CH3:3].N1CC(OC2C=CC([CH2:35][N:36]([CH3:38])[CH3:37])=C(C)C=2)C1.CN1CCNCC1.[Cl:47]C1C=C(O)C=CC=1C=O>>[NH:12]1[CH2:11][CH:10]([O:9][C:8]2[CH:21]=[CH:22][C:5]([CH2:4][N:2]3[CH2:1][CH2:37][N:36]([CH3:38])[CH2:35][CH2:3]3)=[C:6]([Cl:47])[CH:7]=2)[CH2:13]1
참가 물질실험 절차출처 및 근거반응 노트

참가 물질

5

반응물 4

HCID 531671-MethylpiperazineHCID 1853632-Chloro-4-hydroxybenzaldehydeHCID 58043102tert-Butyl 3-(4-((dimethylamino)methyl)-3-methylphenoxy)azetidine-1-carboxylateHCID 666563501-(4-(Azetidin-3-yloxy)-2-methylphenyl)-N,N-dimethylmethanamine

생성물 1

HCID 666532661-(4-(Azetidin-3-yloxy)-2-chlorobenzyl)-4-methylpiperazine수율 32%

실험 절차

Using similar protocols as described in Examples 20A, 20B and 20C employing 1-methylpiperazine and 2-chloro-4-hydroxybenzaldehyde as starting material afforded 0.32 g (32%) of 49A as an oil. 1H NMR (500 MHz, CDCl3): δ 2.29 (s, 3H), 2.3-2.7 (m, 8H), 3.55 (s, 2H), 3.78 (m, 2H), 3.92 (m, 2H), 4.96 (m, 1H), 6.64 (d, 1H), 6.74 (d, 1H), 7.31 (m, 1H), MS (APCI+) m/z 296 [M+H]+.

출처 및 근거

ORD 기록
ord-4469e6c2556b4ac6aa741cd08d6e19ac
출처 데이터셋
uspto-grants-2013_10
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08546375B2

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차출처 및 근거반응 노트