Hydrochloric Acid → (3-Methylpyrrolidin-3-yl)methanol hydrochloride

HRID 1035256노트

반응식

HRID 1035256 반응식
[OH:1][CH2:2][C:3]1([CH3:15])[CH2:7][CH2:6][N:5](C(OC(C)(C)C)=O)[CH2:4]1.CO.[ClH:18]>>[ClH:18].[CH3:15][C:3]1([CH2:2][OH:1])[CH2:7][CH2:6][NH:5][CH2:4]1

참가 물질

4

반응물 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 597084561-Boc-3-methylpyrrolidine-3-methanol

생성물 1

HCID 66653455(3-Methylpyrrolidin-3-yl)methanol hydrochloride

실험 절차

tert-butyl 3-(hydroxymethyl)-3-methylpyrrolidine-1-carboxylate (0.31 g, 1.44 mmol, see WO 2009132986) was dissolved in HCl in methanol (1.25M, 3.5 mL, 4.32 mmol). The reaction mixture was stirred at RT overnight and then the mixture was evaporated. Ethanol was added and the mixture was again evaporated to afford 243 mg. The crude product was used in the next step without further purification.

후처리

  1. customthe mixture was evaporated
  2. additionEthanol was added
  3. customthe mixture was again evaporated
  4. customto afford 243 mg
  5. customThe crude product was used in the next step without further purification

출처 및 근거

ORD 기록
ord-6b9f9abe7b2e4461acffaa9c909ff603
출처 데이터셋
uspto-grants-2013_10
특허 번호
US08546375B2

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