Ammonia → HCID 59548516, 화합물

HRID 1035300노트

반응식

HRID 1035300 반응식
C([O:3][C:4](=O)[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[C:11]1[CH:16]=[CH:15][N:14]=[CH:13][C:12]=1[C:17]#[N:18])C.N>CO.[Ni]>[CH:16]1[C:11]2[C:6]3[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=3[C:4](=[O:3])[NH:18][CH2:17][C:12]=2[CH:13]=[N:14][CH:15]=1

참가 물질

5

반응물 2

HCID 222AmmoniaHCID 66769548HCID 66769548, 화합물

생성물 1

HCID 59548516HCID 59548516, 화합물

시약·촉매·용매 2

HCID 935Nickel촉매HCID 887Methanol용매

실험 절차

A mixture of Example 180C (29.4 g, 0.117 mol) and Raney®-nickel (30 g) in 2 L of methanol saturated with NH3 was stirred under H2 (50 psi) at 50° C. for 24 hours. After cooling and removal of the catalyst, the mixture was concentrated under reduced pressure to obtain the title compound which was used without further purification.

후처리

  1. temperatureAfter cooling
  2. customremoval of the catalyst
  3. concentrationthe mixture was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-5066493f0c9045eb9711fc2072dcd3ae
출처 데이터셋
uspto-grants-2013_10
특허 번호
US08546377B2

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