3-(4-Methoxyphenyl)quinoline → 4-Quinolin-3-ylphenol

HRID 1035641노트

반응식

HRID 1035641 반응식
C[O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:10]=[N:11][C:12]3[C:17]([CH:18]=2)=[CH:16][CH:15]=[CH:14][CH:13]=3)=[CH:5][CH:4]=1.[Cl-].[Cl-].[Cl-].[Al+3]>>[N:11]1[C:12]2[C:17](=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH:18]=[C:9]([C:6]2[CH:7]=[CH:8][C:3]([OH:2])=[CH:4][CH:5]=2)[CH:10]=1

참가 물질

3

반응물 2

HCID 41342973-(4-Methoxyphenyl)quinolineHCID 6451240Aluminum(III) Chloride

생성물 1

HCID 117461834-Quinolin-3-ylphenol수율 82%

실험 절차

The compound is prepared by reaction of 3-(4-methoxyphenyl)quinoline with aluminum trichloride (564 mg, 4.23 mmol, 5 eq) according to method F. Purification by column chromatography with dichloromethane/methanol 99/1 as the eluent yields the desired product in a yield of 82%, 156 mg.

후처리

  1. customPurification by column chromatography with dichloromethane/methanol 99/1 as the eluent

출처 및 근거

ORD 기록
ord-34947dd94fd84b3995f4677b80d8b771
출처 데이터셋
uspto-grants-2013_10
특허 번호
US08546392B2

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