Boron tribromide → 6-(4-Hydroxyphenyl)-2-naphthol

HRID 1035647

반응식

HRID 1035647 반응식
C[O:2][C:3]1[CH:12]=[CH:11][C:10]2[C:5](=[CH:6][CH:7]=[C:8]([C:13]3[CH:18]=[CH:17][C:16]([O:19]C)=[CH:15][CH:14]=3)[CH:9]=2)[CH:4]=1.B(Br)(Br)Br>>[OH:19][C:16]1[CH:17]=[CH:18][C:13]([C:8]2[CH:9]=[C:10]3[C:5](=[CH:6][CH:7]=2)[CH:4]=[C:3]([OH:2])[CH:12]=[CH:11]3)=[CH:14][CH:15]=1

참가 물질

3

반응물 2

HCID 25134Boron tribromideHCID 111497342-Methoxy-6-(4-methoxyphenyl)naphthalene

생성물 1

HCID 114590066-(4-Hydroxyphenyl)-2-naphthol수율 98%

실험 절차

The compound is prepared by reaction of 2-methoxy-6-(4-methoxyphenyl)-naphthalene (150 mg, 0.57 mmol, 1 eq) with boron tribromide (3.4 ml, 3.4 mmol, 3 eq) according to method G. Purification by column chromatography with hexane/ethyl acetate 9/1 as the eluent yields the desired product in a yield of 98%, 132 mg.

후처리

  1. customPurification by column chromatography with hexane/ethyl acetate 9/1 as the eluent

출처 및 근거

ORD 기록
ord-115a30c013ea425488c9d55d705f1b01
출처 데이터셋
uspto-grants-2013_10
특허 번호
US08546392B2

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