Hydrochloric Acid → 1-(Oxan-4-yl)piperazine--hydrogen chloride (1/2)

HRID 1035919노트

반응식

HRID 1035919 반응식
[O:1]1[CH2:6][CH2:5][CH:4]([N:7]2[CH2:12][CH2:11][N:10](C(OC(C)(C)C)=O)[CH2:9][CH2:8]2)[CH2:3][CH2:2]1.[ClH:20]>CCOCC>[ClH:20].[ClH:20].[O:1]1[CH2:6][CH2:5][CH:4]([N:7]2[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]2)[CH2:3][CH2:2]1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 46785855HCID 46785855, 화합물

생성물 1

HCID 441204811-(Oxan-4-yl)piperazine--hydrogen chloride (1/2)

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

To a solution of EXAMPLE 128A (3.92 g) in ether was added HCl (25 ml, 2M in ether) and the reaction mixture was stirred for 16 hours at room temperature. The solid product was filtered off, dried and used in next step without further purification.

후처리

  1. filtrationThe solid product was filtered off
  2. customdried
  3. customused in next step without further purification

출처 및 근거

ORD 기록
ord-051c7e16098740868a026f67176f819d
출처 데이터셋
uspto-grants-2013_10
특허 번호
US08546399B2

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