N-bromobutanimide → 5,6-Dibromo-2,3-dihydrobenzofuran
반응식
C1C(=O)N([Br:8])C(=O)C1.[Br:9][C:10]1[CH:11]=[CH:12][C:13]2[CH2:17][CH2:16][O:15][C:14]=2[CH:18]=1>C(#N)C>[Br:8][C:11]1[C:10]([Br:9])=[CH:18][C:14]2[O:15][CH2:16][CH2:17][C:13]=2[CH:12]=1참가 물질
4
실험 절차
NBS (450 mg, 2.53 mmol) was added to a solution of 6-bromo-2,3-dihydrobenzo[b]furan (137) (504 mg, 2.53 mmol) in 15 ml ACN. The reaction mixture was stirred overnight at r.t. The yellow solution was poured into ice-water, extracted with EA. Org. phase was washed with aq. sodium bicarbonate and brine subsequently. After dried over sodium sulfate the org. phase was concentrated to give 676 mg (purity ca. 90%) title compound as dark oil which solidified after standing at r.t.
후처리
- extractionextracted with EA
- washphase was washed with aq. sodium bicarbonate and brine subsequently
- dry with materialAfter dried over sodium sulfate the org
- concentrationphase was concentrated
출처 및 근거
- ORD 기록
- ord-6261de30ab2b4d1286b75c9d56757b55
- 출처 데이터셋
- uspto-grants-2013_10
- 특허 번호
- US08546403B2
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