Hydrochloric Acid → 6-(1-aminoethyl)-3,3-dimethylbenzo[c][1,2]oxaborol-1(3H)-ol hydrochloride

HRID 1037046노트

반응식

HRID 1037046 반응식
[OH:1][B:2]1[C:6]2[CH:7]=[C:8]([CH:11]([NH:13]C(=O)OC(C)(C)C)[CH3:12])[CH:9]=[CH:10][C:5]=2[C:4]([CH3:22])([CH3:21])[O:3]1.[ClH:23].O>CO>[ClH:23].[NH2:13][CH:11]([C:8]1[CH:9]=[CH:10][C:5]2[C:4]([CH3:21])([CH3:22])[O:3][B:2]([OH:1])[C:6]=2[CH:7]=1)[CH3:12]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 962WaterHCID 86685492Tert-butyl 1-(1-hydroxy-3,3-dimethyl-1,3-dihydrobenzo[c][1,2]oxaborol-6-yl)ethylcarbamate

생성물 1

HCID 866854936-(1-aminoethyl)-3,3-dimethylbenzo[c][1,2]oxaborol-1(3H)-ol hydrochloride

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A mixture of tert-butyl 1-(1-hydroxy-3,3-dimethyl-1,3-dihydrobenzo[c][1,2]oxaborol-6-yl)ethyl-carbamate (0.93 mmol) in MeOH (10 mL) was added 6N HCl (10 mL). The mixture was stirred at rt overnight. The mixture was poured into water and washed with EA (50 mL×2). The water layer was lyophilized to give crude 6-(1-aminoethyl)-3,3-dimethylbenzo[c][1,2]oxaborol-1(3H)-ol hydrochloride. It was used in the next step without further purification.

후처리

  1. washwashed with EA (50 mL×2)

출처 및 근거

ORD 기록
ord-4b99f6c047e54e49b0c6dfdcf93dc7e0
출처 데이터셋
uspto-grants-2013_10
특허 번호
US08546357B2

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