Hydroxyamine hydrochloride → HCID 89573941, 화합물

HRID 1037068노트

반응식

HRID 1037068 반응식
[CH:1]([C:3]1[N:4]2[C:8]([C:9]([C:12]([O:14][CH3:15])=[O:13])=[CH:10][CH:11]=1)=[CH:7][CH:6]=[CH:5]2)=O.[NH2:16][OH:17].Cl.CC([O-])=O.[Na+]>C1COCC1.O>[OH:17]/[N:16]=[CH:1]/[C:3]1[N:4]2[C:8]([C:9]([C:12]([O:14][CH3:15])=[O:13])=[CH:10][CH:11]=1)=[CH:7][CH:6]=[CH:5]2

참가 물질

6

반응물 3

HCID 443297Hydroxyamine hydrochlorideHCID 517045Sodium AcetateHCID 86685513Methyl 5-formylindolizine-8-carboxylate

생성물 1

HCID 89573941HCID 89573941, 화합물

시약·촉매·용매 2

HCID 962Water용매HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of methyl 5-formylindolizine-8-carboxylate (203 mg, 1.0 mmol) and NH2OH.HCl (105 mg, 1.5 mmol) in THF (30 mL) and H2O (8 mL) at rt was added NaOAc (164 mg, 2.0 mmol). The reaction mixture was stirred at rt for 2 h. The mixture was extracted with EA (2×40 mL). The organic layers was dried over Na2SO4, filtered and concentrated under reduced pressure. The residue was used in next step without further purification.

후처리

  1. extractionThe mixture was extracted with EA (2×40 mL)
  2. dry with materialThe organic layers was dried over Na2SO4
  3. filtrationfiltered
  4. concentrationconcentrated under reduced pressure
  5. customThe residue was used in next step without further purification

출처 및 근거

ORD 기록
ord-8095406ef31b411c8de29b3c599cb6fe
출처 데이터셋
uspto-grants-2013_10
특허 번호
US08546357B2

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