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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
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HCID 67776061, 화합물 → HCID 67776316, 화합물

HRID 1037529
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인쇄 미리보기

반응식

HRID 1037529 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:16]([C:17]([NH:19][CH3:20])=[O:18])=[C:15]3[C:10]([CH:11]=[C:12]([N+:24]([O-])=O)[C:13]([CH:21]4[CH2:23][CH2:22]4)=[CH:14]3)=[N:9]2)=[CH:4][CH:3]=1>C1COCC1.CO.[Ni]>[NH2:24][C:12]1[C:13]([CH:21]2[CH2:23][CH2:22]2)=[CH:14][C:15]2[C:10]([CH:11]=1)=[N:9][N:8]([C:5]1[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][CH:6]=1)[C:16]=2[C:17]([NH:19][CH3:20])=[O:18]
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 1

HCID 67776061HCID 67776061, 화합물

생성물 1

HCID 67776316HCID 67776316, 화합물수율 83.7%

시약·촉매·용매 3

HCID 935Nickel촉매HCID 887Methanol용매2회HCID 8028Tetrahydrofuran용매

반응 조건

온도
60 °C

실험 절차

To a solution of 2-(4-chlorophenyl)-5-cyclopropyl-N-methyl-6-nitro-2H-indazole-3-carboxamide (127 mg, 0.34 mmol) in THF (2.5 mL) and MeOH (7.5 mL) was added Raney nickel (20 mg) and the reaction was stirred vigorously under an atmosphere of hydrogen at 60° C. for 2 h. The reaction mixture was diluted with MeOH (40 mL), filtered and then concentrated to dryness to give 6-amino-2-(4-chlorophenyl)-5-cyclopropyl-N-methyl-2H-indazole-3-carboxamide as a tan solid (97 mg, 83%).

후처리

  1. filtrationfiltered
  2. concentrationconcentrated to dryness

출처 및 근거

ORD 기록
ord-6cf51ca15703427880c06aec4351012a
출처 데이터셋
uspto-grants-2013_10
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08546389B2

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