Stannous Chloride → 5-Amino-2-(2-dimethylamino-ethyl)-2H-isoquinolin-1-one

HRID 1037759노트

반응식

HRID 1037759 반응식
[CH3:1][N:2]([CH3:19])[CH2:3][CH2:4][N:5]1[CH:14]=[CH:13][C:12]2[C:7](=[CH:8][CH:9]=[CH:10][C:11]=2[N+:15]([O-])=O)[C:6]1=[O:18].[Sn](Cl)Cl>C1COCC1>[NH2:15][C:11]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:12]=1[CH:13]=[CH:14][N:5]([CH2:4][CH2:3][N:2]([CH3:19])[CH3:1])[C:6]2=[O:18]

참가 물질

4

반응물 2

HCID 24479Stannous ChlorideHCID 595792672-(2-Dimethylamino-ethyl)-5-nitro-2H-isoquinolin-1-one

생성물 1

HCID 595794535-Amino-2-(2-dimethylamino-ethyl)-2H-isoquinolin-1-one

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

2-(2-Dimethylamino-ethyl)-5-nitro-2H-isoquinolin-1-one (0.67 g, 2.6 mmol) and dehydrate tin dichloride (2 g, 10 mml) were stirred in THF (10 mL) at room temperature for 24 hours. The volatiles were removed via rotovapor, and the residue was dissolved in CH2Cl2 (1 L), washed with aqueous saturated NaHCO3 solution (30 mL×3). The organic layer was dried over Na2SO4, filtered and concentrated to dryness gave 5-Amino-2-(2-dimethylamino-ethyl)-2H-isoquinolin-1-one as a yellow solid. The compound was used for next steps without further purification.

후처리

  1. customThe volatiles were removed via rotovapor
  2. dissolutionthe residue was dissolved in CH2Cl2 (1 L)
  3. washwashed with aqueous saturated NaHCO3 solution (30 mL×3)
  4. dry with materialThe organic layer was dried over Na2SO4
  5. filtrationfiltered
  6. concentrationconcentrated to dryness

출처 및 근거

ORD 기록
ord-b77dc1712f8e4d5ca9009d9e2cc01e18
출처 데이터셋
uspto-grants-2013_10
특허 번호
US08546579B2

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