Hydrochloric Acid → 2-(2-Methoxyethoxy)benzoic acid

HRID 1037834노트

반응식

HRID 1037834 반응식
C[O:2][C:3](=[O:15])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[O:10][CH2:11][CH2:12][O:13][CH3:14].Cl>[OH-].[K+].O>[CH3:14][O:13][CH2:12][CH2:11][O:10][C:5]1[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=1[C:3]([OH:15])=[O:2]

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 22381872Methyl 2-(2-methoxyethoxy)benzoate

생성물 1

HCID 134171032-(2-Methoxyethoxy)benzoic acid수율 98%

시약·촉매·용매 2

HCID 962Water용매HCID 14797Potassium Hydroxide용매

실험 절차

A mixture of the product of Example 25A (0.27 g, 1.3 mmol) in 40% aqueous potassium hydroxide was stirred for 6 hours. The mixture was then diluted with water, made slightly acidic by the addition of 2 N aqueous HCl, and then extracted three times with ethyl acetate. The combined organic extracts were dried over magnesium sulfate, filtered, and concentrated under reduced pressure to afford 0.25 g of the title compound.

후처리

  1. extractionextracted three times with ethyl acetate
  2. dry with materialThe combined organic extracts were dried over magnesium sulfate
  3. filtrationfiltered
  4. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-830210465716414ea2e5e63beed575fa
출처 데이터셋
uspto-grants-2013_10
특허 번호
US08546583B2

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