Hydrochloric Acid → Benzyl 2-(1-aminoethyl)thiazole-5-carboxylate hydrochloride
반응식
C(OC([NH:8][CH:9]([C:11]1[S:12][C:13]([C:16]([O:18][CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[O:17])=[CH:14][N:15]=1)[CH3:10])=O)(C)(C)C.[ClH:26]>C1COCC1.O1CCOCC1>[ClH:26].[NH2:8][CH:9]([C:11]1[S:12][C:13]([C:16]([O:18][CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[O:17])=[CH:14][N:15]=1)[CH3:10]참가 물질
5
실험 절차
To a solution of benzyl 2-(1-(tert-butoxycarbonylamino)ethyl)thiazole-5-carboxylate (0.55 g, 0.55 mmol) in THF (2 mL) was added 4M HCl in dioxane (0.5 ml). The reaction solution was stirred at room temperature overnight. The solution was concentrated to dryness to afford a colorless oil (0.45 g, 100%). LC-MS: (FA) ES+ 263.
후처리
- concentrationThe solution was concentrated to dryness
출처 및 근거
- ORD 기록
- ord-cd2b50c9553b47638568e4594a66f0e4
- 출처 데이터셋
- uspto-grants-2013_10
- 특허 번호
- US08546588B2
반응 노트
불러오는 중…