Trifluoroacetic acid → HCID 58884968, 화합물

HRID 1038071노트

반응식

HRID 1038071 반응식
[CH3:1][O:2][C:3](=[O:10])[C:4]([C:6]([F:9])([F:8])[F:7])=[CH2:5].O([CH2:13][N:14]([CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)[CH2:15][Si](C)(C)C)C.FC(F)(F)C(O)=O>ClCCl>[CH3:1][O:2][C:3]([C:4]1([C:6]([F:9])([F:8])[F:7])[CH2:5][CH2:13][N:14]([CH2:20][C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=2)[CH2:15]1)=[O:10]

참가 물질

5

반응물 3

HCID 6422Trifluoroacetic acidHCID 353442Benzyl(methoxymethyl)((trimethylsilyl)methyl)amineHCID 2782391Methyl 2-(trifluoromethyl)acrylate

생성물 1

HCID 58884968HCID 58884968, 화합물수율 76.2%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a stirred cold solution (0° C.) of 2-trifluoromethyl-acrylic acid methyl ester (308 mg, 2 mmol) and N-(methoxylmethyl)-N-(trimethylsilylmethyl)benzylamine (529 μl, 4.8 mmol) in dichloromethane (3 ml) was added slowly trifluoroacetic acid (31 μl). The resulting solution was allowed to stir at rt overnight and directly purified by column chromatography eluting with ethyl acetate in hexane (1:4) to provide 1-benzyl-3-trifluoromethyl-pyrrolidine-3-carboxylic acid methyl ester as oil (438 mg, 76%).

후처리

  1. customdirectly purified by column chromatography
  2. washeluting with ethyl acetate in hexane (1:4)

출처 및 근거

ORD 기록
ord-0416ea96d91c447dac657ae4c9f0f925
출처 데이터셋
uspto-grants-2013_10
특허 번호
US08546404B2

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