Diisopropylethylamine → HCID 86630171, 화합물

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[CH:1]([O:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]2[C:19]3[C:14](=[CH:15][CH:16]=[C:17]([NH:20][C:21]([C:23]4([O:28][CH3:29])[CH2:27][CH2:26][NH:25][CH2:24]4)=[O:22])[CH:18]=3)[NH:13][N:12]=2)=[CH:7][CH:6]=1)([CH3:3])[CH3:2].Cl[CH2:31][C:32]([N:34]1[CH2:39][CH2:38][N:37]([C:40]2[CH:45]=[CH:44][C:43]([C:46]3[N:51]=[CH:50][CH:49]=[CH:48][N:47]=3)=[C:42]([F:52])[CH:41]=2)[CH2:36][CH2:35]1)=[O:33].C(N(C(C)C)CC)(C)C>CN(C)C=O>[CH:1]([O:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]2[C:19]3[C:14](=[CH:15][CH:16]=[C:17]([NH:20][C:21]([C:23]4([O:28][CH3:29])[CH2:27][CH2:26][N:25]([CH2:31][C:32]([N:34]5[CH2:39][CH2:38][N:37]([C:40]6[CH:45]=[CH:44][C:43]([C:46]7[N:47]=[CH:48][CH:49]=[CH:50][N:51]=7)=[C:42]([F:52])[CH:41]=6)[CH2:36][CH2:35]5)=[O:33])[CH2:24]4)=[O:22])[CH:18]=3)[NH:13][N:12]=2)=[CH:7][CH:6]=1)([CH3:3])[CH3:2]

참가 물질

실험 절차

3-Methoxy-pyrrolidine-3-carboxylic acid [3-(4-isopropoxy-phenyl)-1H-indazol-5-yl]-amide (8AB) (40 mg, 0.086 mmol, 1 equiv) and 2-Chloro-1-[4-(3-fluoro-4-pyrimidin-2-yl-phenyl)-piperazin-1-yl]-ethanone (7AB) (35 mg, 0.103 mmol, 1.2 equiv) were weighed out in a flask, and to it was added N,N-dimethylformamide (3 mL) and diisopropylethylamine (22 mg, 30 uL, 0.172 mmol, 2 equiv). The reaction content was stirred at room temperature, overnight.