Hydrochloric Acid → 3-[(2-Methoxyethyl)(methyl)amino]-1H-indazole-5-carbaldehyde
반응식
[O:1]1CCCO[CH:2]1[C:7]1[CH:8]=[C:9]2[C:13](=[CH:14][CH:15]=1)[NH:12][N:11]=[C:10]2[N:16]([CH2:18][CH2:19][O:20][CH3:21])[CH3:17].Cl>C(O)C>[CH3:21][O:20][CH2:19][CH2:18][N:16]([CH3:17])[C:10]1[C:9]2[C:13](=[CH:14][CH:15]=[C:7]([CH:2]=[O:1])[CH:8]=2)[NH:12][N:11]=1참가 물질
4
반응 조건
- 온도
- 90 °C
실험 절차
To a solution of 170 mg (0.583 mmol) 5-(1,3-dioxan-2-yl)-N-(2-methoxyethyl)-N-methyl-1H-indazol-3-amine (Example 47A) in ethanol (10 ml) were added 1.9 ml (5.83 mmol) 3 M hydrochloric acid, and the solution was heated to 90° C. for 30 min. After cooling, the mixture was concentrated under reduced pressure. The remaining material (135 mg, 99% of th.) was used in the next step without further purification.
후처리
- temperatureAfter cooling
- concentrationthe mixture was concentrated under reduced pressure
- customThe remaining material (135 mg, 99% of th.) was used in the next step without further purification
출처 및 근거
- ORD 기록
- ord-e0f139e2222f48a88e79c866efc34628
- 출처 데이터셋
- uspto-grants-2013_10
- 특허 번호
- US08551989B2
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