5-nitro-2-(1H-1,2,4-triazol-1-yl)pyridine → 6-(1H-1,2,4-Triazol-1-yl)pyridin-3-amine

HRID 1039062

반응식

HRID 1039062 반응식
[N+:1]([C:4]1[CH:5]=[CH:6][C:7]([N:10]2[CH:14]=[N:13][CH:12]=[N:11]2)=[N:8][CH:9]=1)([O-])=O>[Pd].CO>[N:10]1([C:7]2[N:8]=[CH:9][C:4]([NH2:1])=[CH:5][CH:6]=2)[CH:14]=[N:13][CH:12]=[N:11]1

참가 물질

4

반응물 1

HCID 27667645-nitro-2-(1H-1,2,4-triazol-1-yl)pyridine

생성물 1

HCID 167723276-(1H-1,2,4-Triazol-1-yl)pyridin-3-amine

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

5-nitro-2-(1H-1,2,4-triazol-1-yl)pyridine (100 mg, 0.523 mmol) from step 1 of this example was added Pd/C (111 mg, 0.105 mmol) and methanol (5.2 mL). Set the reaction on Parr Shaker at 50 psi (345 kPa) for overnight. The solution was filtered through CELITE and rinsed with methanol to give the title compound as a white solid.

후처리

  1. customthe reaction on Parr Shaker at 50 psi (345 kPa) for overnight
  2. filtrationThe solution was filtered through CELITE
  3. washrinsed with methanol

출처 및 근거

ORD 기록
ord-fbe714709af342a7b7b3c79361752d35
출처 데이터셋
uspto-grants-2013_10
특허 번호
US08552022B2

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