Ammonia → 5-Amino-2,3-dihydro-isoindol-1-one

HRID 1039087

반응식

HRID 1039087 반응식
O.Cl.[N+:3]([C:6]1[CH:7]=[C:8]2[C:12](=[CH:13][CH:14]=1)[C:11](=[O:15])[NH:10][CH2:9]2)([O-])=O.N>CCO.[Fe]>[NH2:3][C:6]1[CH:7]=[C:8]2[C:12](=[CH:13][CH:14]=1)[C:11](=[O:15])[NH:10][CH2:9]2

참가 물질

7

반응물 4

HCID 222AmmoniaHCID 313Hydrochloric AcidHCID 962WaterHCID 140056255-nitro-2,3-dihydro-1H-isoindol-1-one

생성물 1

HCID 219562395-Amino-2,3-dihydro-isoindol-1-one

시약·촉매·용매 2

HCID 23925Iron촉매HCID 702Ethanol용매

반응 조건

온도
95 °C

실험 절차

Iron powder (2.51 g, 45 mmol), water (0.97 ml) and HCl (37%, 0.74 ml), were added to a stirred suspension of the 5-nitroisoindolin-1-one (800 mg, 4.5 mmol) from step 2 of this example in EtOH (11.2 ml). The mixture was heated at 95° C. for 2 h. Ammonia (7N in MeOH) was added (1 mL) to make the pH of the mixture alkaline. The mixture was filtered to removed undissolved solids and the filter cake washed with EtOH (2×40 ml). The filtrate and organic washes were combined and concentrated in vacuum to give the titled compound.

후처리

  1. filtrationThe mixture was filtered
  2. customto removed undissolved solids
  3. washthe filter cake washed with EtOH (2×40 ml)
  4. concentrationconcentrated in vacuum

출처 및 근거

ORD 기록
ord-c3d19c53996c4330be95266fb33456dd
출처 데이터셋
uspto-grants-2013_10
특허 번호
US08552022B2

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