Ethyl Acetate → 1-Hydrazinothiocarbonylpiperidin-4-ol
반응식
[NH:1]([C:3](=[S:6])OC)[NH2:2].[NH:7]1[CH2:12][CH2:11][CH:10]([OH:13])[CH2:9][CH2:8]1.C(OCC)(=O)C>C(O)C>[NH:1]([C:3]([N:7]1[CH2:12][CH2:11][CH:10]([OH:13])[CH2:9][CH2:8]1)=[S:6])[NH2:2]참가 물질
5
반응 조건
- 온도
- 90 °C
실험 절차
A solution of methyl hydrazinecarbothioate (1.0 g, 8.2 mmol) and piperidin-4-ol (1.24 g, 12.3 mmol) in ethanol (7 mL) was refluxed with heating at 90° C. for 2 days. After addition of ethyl acetate, the reaction solution was washed with saturated aqueous sodium chloride, dried over anhydrous magnesium sulfate and concentrated to give the crude desired product. The crude product was used directly for the next reaction.
후처리
- washthe reaction solution was washed with saturated aqueous sodium chloride
- dry with materialdried over anhydrous magnesium sulfate
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-ffdf41338bfb4baf90c4987ed35a4d2c
- 출처 데이터셋
- uspto-grants-2013_10
- 특허 번호
- US08552031B2
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