Sodium Carbonate → methyl 5-(N-hydroxycarbamimidoyl)pentanoate
반응식
C(=O)([O-])[O-].[Na+].[Na+].[CH3:7][O:8][C:9](=[O:16])[CH2:10][CH2:11][CH2:12][CH2:13][C:14]#[N:15].Cl.[NH2:18][OH:19]>C(O)C>[OH:19][NH:18][C:14]([CH2:13][CH2:12][CH2:11][CH2:10][C:9]([O:8][CH3:7])=[O:16])=[NH:15]참가 물질
5
실험 절차
Add sodium carbonate (4.5 g, 42 mmol) to a solution of commercially available 5-cyano-pentanoic acid methyl ester (5.0 g, 35 mmol) and hydroxylamine hydrochloride (2.9 g, 42 mmol) in ethanol (100 mL) at room temperature under nitrogen and heat the mixture at reflux for 5.5 h. Filter the mixture through celite and remove the solvent under reduced pressure to provide crude methyl 5-(N-hydroxycarbamimidoyl)pentanoate (5.3 g, 87% yield), which is carried forward without further purification.
후처리
- temperatureheat the mixture
- temperatureat reflux for 5.5 h
- filtrationFilter the mixture through celite
- customremove the solvent under reduced pressure
출처 및 근거
- ORD 기록
- ord-7e662e83efbc49e9b4a38efd8381f4ea
- 출처 데이터셋
- uspto-grants-2013_10
- 특허 번호
- US08552039B2
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