Sodium Carbonate → methyl 5-(N-hydroxycarbamimidoyl)pentanoate

HRID 1039186

반응식

HRID 1039186 반응식
C(=O)([O-])[O-].[Na+].[Na+].[CH3:7][O:8][C:9](=[O:16])[CH2:10][CH2:11][CH2:12][CH2:13][C:14]#[N:15].Cl.[NH2:18][OH:19]>C(O)C>[OH:19][NH:18][C:14]([CH2:13][CH2:12][CH2:11][CH2:10][C:9]([O:8][CH3:7])=[O:16])=[NH:15]

참가 물질

5

반응물 3

HCID 10340Sodium CarbonateHCID 443297Hydroxyamine hydrochlorideHCID 554130Methyl 5-cyanopentanoate

생성물 1

HCID 178500328methyl 5-(N-hydroxycarbamimidoyl)pentanoate수율 87%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Add sodium carbonate (4.5 g, 42 mmol) to a solution of commercially available 5-cyano-pentanoic acid methyl ester (5.0 g, 35 mmol) and hydroxylamine hydrochloride (2.9 g, 42 mmol) in ethanol (100 mL) at room temperature under nitrogen and heat the mixture at reflux for 5.5 h. Filter the mixture through celite and remove the solvent under reduced pressure to provide crude methyl 5-(N-hydroxycarbamimidoyl)pentanoate (5.3 g, 87% yield), which is carried forward without further purification.

후처리

  1. temperatureheat the mixture
  2. temperatureat reflux for 5.5 h
  3. filtrationFilter the mixture through celite
  4. customremove the solvent under reduced pressure

출처 및 근거

ORD 기록
ord-7e662e83efbc49e9b4a38efd8381f4ea
출처 데이터셋
uspto-grants-2013_10
특허 번호
US08552039B2

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