Sodium borohydride → 1-(2-Chloropyrimidin-4-yl)ethanol
반응식
[Cl:1][C:2]1[N:7]=[C:6]([C:8](=[O:10])[CH3:9])[CH:5]=[CH:4][N:3]=1.[BH4-].[Na+]>CO.CCOC(C)=O>[Cl:1][C:2]1[N:7]=[C:6]([CH:8]([OH:10])[CH3:9])[CH:5]=[CH:4][N:3]=1참가 물질
5
실험 절차
To a solution of 1-(2-chloropyrimidin-4-yl)ethanone (600 mg, 3.83 mmol) in MeOH (5 mL) at 0° C. was added sodium borohydride (145 mg, 3.83 mmol) and stirred for 30 min. The solution was diluted with EtOAc, washed with brine, dried with MgSO4, filtered, and concentrated to dryness to afford 1-(2-chloropyrimidin-4-yl)ethanol (220 mg, 1.39 mmol, 36% yield). MS ESI: [M+H]+ m/z 159.0. 1H NMR (500 MHz, CDCl3) δ 8.60 (d, J=5.1, 1H), 7.39 (d, J=5.1, 1H), 4.87 (q, J=6.6, 1H), 1.53 (m, 3H).
후처리
- washwashed with brine
- dry with materialdried with MgSO4
- filtrationfiltered
- concentrationconcentrated to dryness
출처 및 근거
- ORD 기록
- ord-2aaa2a3e566c4cfb9145484d421b5c33
- 출처 데이터셋
- uspto-grants-2013_10
- 특허 번호
- US08551984B2
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