Pyridine → 5-(4-Fluorophenyl)-3-(2-piperidinyl)pyridine fumarate

반응식

N1C=CC=CC=1.[C:7]([OH:14])(=[O:13])/[CH:8]=[CH:9]/[C:10]([OH:12])=[O:11].[F:15][C:16]1[CH:21]=[CH:20][C:19]([C:22]2[CH:23]=[C:24]([CH:28]3[CH2:33][CH2:32][CH2:31][CH2:30][NH:29]3)[CH:25]=[N:26][CH:27]=2)=[CH:18][CH:17]=1>CO>[C:7]([OH:14])(=[O:13])/[CH:8]=[CH:9]/[C:10]([OH:12])=[O:11].[F:15][C:16]1[CH:17]=[CH:18][C:19]([C:22]2[CH:23]=[C:24]([CH:28]3[CH2:33][CH2:32][CH2:31][CH2:30][NH:29]3)[CH:25]=[N:26][CH:27]=2)=[CH:20][CH:21]=1

참가 물질

실험 절차

The above described pyridine derivative was converted into invention compound of Formula I by the addition of one equivalent of fumaric acid to a methanol (15 mL) solution of the free amine at 25° C. After 30 minutes the solvent was removed in vacuo and the residue pumped under high vacuum. Trituration with diethyl ether resulted in the formation of 5-(4-fluorophenyl)-3-(2-piperidinyl)pyridine fumarate (70%) as a colorless solid.