Hydrochloric Acid → 6-(2-Hydroxypropan-2-yl)-3,4'-bipyridine-2'-carboxylic acid hydrochloride salt

반응식

[OH:1][C:2]([C:5]1[N:10]=[CH:9][C:8]([C:11]2[CH:16]=[CH:15][N:14]=[C:13]([C:17]([O:19]C(C)C)=[O:18])[CH:12]=2)=[CH:7][CH:6]=1)([CH3:4])[CH3:3].[ClH:23]>>[ClH:23].[OH:1][C:2]([C:5]1[N:10]=[CH:9][C:8]([C:11]2[CH:16]=[CH:15][N:14]=[C:13]([C:17]([OH:19])=[O:18])[CH:12]=2)=[CH:7][CH:6]=1)([CH3:4])[CH3:3]

참가 물질

반응물 2

HCID 313Hydrochloric Acid

HCID 66848234Isopropyl 6-(2-hydroxypropan-2-yl)-3,4'-bipyridine-2'-carboxylate

생성물 1

HCID 668482386-(2-Hydroxypropan-2-yl)-3,4'-bipyridine-2'-carboxylic acid hydrochloride salt수율 87%

실험 절차

A solution of isopropyl 6-(2-hydroxypropan-2-yl)-3,4′-bipyridine-2′-carboxylate (140 mg, 0.47 mmol) in 1 M hydrochloric acid (2 mL) was heated at 100° C. overnight. The solvent was removed under reduced pressure to give 6-(2-hydroxypropan-2-yl)-3,4′-bipyridine-2′-carboxylic acid hydrochloride salt as a white powder (106 mg, 87%). 259.1 (M+1).

후처리

customThe solvent was removed under reduced pressure

출처 및 근거

ORD 기록: ord-2a860bd136a147b290ca621b956f6c07
출처 데이터셋: uspto-grants-2013_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08552196B2

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