Hydrochloric Acid → (R)-5-(Pyrrolidin-3-yl)-2H-tetrazole
반응식
C(OC([N:8]1[CH2:12][CH2:11][C@@H:10]([C:13]2[N:14]=[N:15][NH:16][N:17]=2)[CH2:9]1)=O)(C)(C)C.Cl.O1CCOCC1>CO>[NH:8]1[CH2:12][CH2:11][C@@H:10]([C:13]2[N:14]=[N:15][NH:16][N:17]=2)[CH2:9]1참가 물질
5
실험 절차
(R)-3-(2H-Tetrazol-5-yl)-pyrrolidine-1-carboxylic acid tert-butyl ester (600 mg, 2.51 mmol) was dissolved in methanol (20 mL), 4M HCl in dioxane (1.13 ml, 4.52 mmol) was then added dropwise. The solution was stirred overnight. The reaction was concentrated in vacuo. The residue was purified by reverse phase HPLC to afford (R)-5-pyrrolidin-3-yl-2H-tetrazole (220 mg, 1.58 mmol, 63%) as a white solid.
후처리
- concentrationThe reaction was concentrated in vacuo
- customThe residue was purified by reverse phase HPLC
출처 및 근거
- ORD 기록
- ord-69d661ae2896405fbf64328ef0f9f503
- 출처 데이터셋
- uspto-grants-2013_10
- 특허 번호
- US08552205B2
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