Hydrochloric Acid → ((S)-2-Amino-propionylamino)-pyridin-2-yl-acetic acid methyl ester

HRID 1040460노트

반응식

HRID 1040460 반응식
[CH3:1][O:2][C:3](=[O:24])[CH:4]([NH:11][C:12](=[O:23])[C@@H:13]([NH:15]C(OC(C)(C)C)=O)[CH3:14])[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][N:6]=1.Cl>O1CCOCC1>[CH3:1][O:2][C:3](=[O:24])[CH:4]([NH:11][C:12](=[O:23])[C@@H:13]([NH2:15])[CH3:14])[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][N:6]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 67390971HCID 67390971, 화합물

생성물 1

HCID 58431125((S)-2-Amino-propionylamino)-pyridin-2-yl-acetic acid methyl ester수율 113.8%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매2회

실험 절차

To a solution of ((S)-2-tert-Butoxycarbonylamino-propionylamino)-pyridin-2-yl-acetic acid methyl ester (337 mg, 1.00 mmol) in dioxane (2 mL) was added 4 N HCl in dioxane (1.00 mL, 4.00 mmol). The reaction was stirred at room temperature for 1 h. Removal of solvents in vacuo provided the title compound ((S)-2-Amino-propionylamino)-pyridin-2-yl-acetic acid methyl ester (270 mg) as a HCl salt, m/z 210.96 [M+1]+

후처리

  1. customRemoval of solvents in vacuo

출처 및 근거

ORD 기록
ord-576345e02bbc41e2be06fdef65f11532
출처 데이터셋
uspto-grants-2013_10
특허 번호
US08552205B2

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