Diethyl Ether → HCID 58430895, 화합물

HRID 1040469노트

반응식

HRID 1040469 반응식
Cl.[CH:2]1([CH2:5]C(=N)OCC)[CH2:4][CH2:3]1.C(=O)([O-])[O-].[K+].[K+].Cl.[NH2:18][CH2:19][C:20]#[N:21].[CH3:22][CH2:23][O:24]CC>O>[CH2:23]([O:24][C:5]([CH:2]1[CH2:3][CH2:4]1)=[N:21][CH2:20][C:19]#[N:18])[CH3:22]

참가 물질

6

반응물 4

HCID 3283Diethyl EtherHCID 11430Potassium CarbonateHCID 11491918Aminoacetonitrile hydrochlorideHCID 14860732Ethyl 2-cyclopropylethanecarboximidate hydrochloride

생성물 1

HCID 58430895HCID 58430895, 화합물

시약·촉매·용매 1

HCID 962Water용매2회

실험 절차

To a suspension of ethyl cyclopropylacetimidate hydrochloride (6.0 g, 53 mmol) in ether (50 mL) was added anhydrous potassium carbonate (7.3 g, 53 mmol). After stirring for 5 min, a solution of aminoacetonitrile hydrochloride (4.9 g, 53 mmol) in water (40 mL) was added and the mixture stirred for additional 90 min. The reaction was diluted with water (100 mL) and extracted with ether (2×300 mL). The combined organic fractions were dried (Na2SO4), filtered, and concentrated to give N-cyanomethyl-cyclopropanecarboximidic acid ethyl ester as a liquid (4.54 g).

후처리

  1. stirringthe mixture stirred for additional 90 min
  2. extractionextracted with ether (2×300 mL)
  3. dry with materialThe combined organic fractions were dried (Na2SO4)
  4. filtrationfiltered
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-4068d6d00af54e1d8378c89ccb98a1f8
출처 데이터셋
uspto-grants-2013_10
특허 번호
US08552205B2

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