Triethylamine → HCID 86669120, 화합물

HRID 1041830

반응식

HRID 1041830 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5](O)=[C:4]([CH:9]2[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]2)[CH:3]=1.C(N(CC)CC)C.[F:22][C:23]([F:36])([F:35])[S:24]([O:27]S(C(F)(F)F)(=O)=O)(=[O:26])=[O:25]>CN(C)C1C=CN=CC=1.ClCCl>[F:22][C:23]([F:36])([F:35])[S:24]([OH:27])(=[O:26])=[O:25].[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH:9]2[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]2)[CH:3]=1

참가 물질

6

반응물 3

HCID 8471TriethylamineHCID 67749Trifluoromethanesulfonic anhydrideHCID 831204-Chloro-2-cyclohexylphenol

생성물 1

HCID 86669120HCID 86669120, 화합물

시약·촉매·용매 2

HCID 142844-(Dimethylamino)pyridine촉매HCID 6344Dichloromethane용매

반응 조건

온도
-5 °C

실험 절차

19 g (90.2 mmol) of 4-chloro-2-cyclohexylphenol, 4.64 ml (33.18 mmol) of triethylamine and 223 mg (1.8 mmol) of 4-(dimethylamino)pyridine are dissolved in 264 ml of dichloromethane, the mixture is cooled to −5° C., and 29.6 ml (180 mmol) of trifluoromethanesulfonic anhydride are added dropwise. The batch is stirred overnight at room temperature and filtered through silica gel with dichloromethane, giving the product 7, which is employed in the next step without further purification.

후처리

  1. filtrationfiltered through silica gel with dichloromethane

출처 및 근거

ORD 기록
ord-55f07e4467df4f35a9840a534c5bfa5b
출처 데이터셋
uspto-grants-2013_10
특허 번호
US08557142B2

연결된 노트

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