Methyl morpholine oxide → 1-(8-Bromoquinolin-2-yl)ethane-1,2-diol
반응식
[Br:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[N:10]=C(C=C)[CH:8]=[CH:7]2.C[N+]1([O-])CC[O:18]CC1.[CH3:22][C:23]([CH3:25])=[O:24].O>ClCCl.O=[Os](=O)(=O)=O>[Br:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[N:10]=[C:22]([CH:23]([OH:24])[CH2:25][OH:18])[CH:8]=[CH:7]2참가 물질
6
실험 절차
To 8-bromo-2-vinylquinoline (0.886 g, 3.78 mmol) in acetone/H2O (8 mL/2 mL) was added 4-methylmorpholine N-oxide (1.06 g, 4.54 mmol) followed by OsO4 (0.5 mL, 2.5% in t-BuOH). The reaction mixture was stirred for two hours at ambient temperature then diluted with dichloromethane. The organic layer was washed with saturated sodium sulfate and brine and concentrated to give crude product.
후처리
- washThe organic layer was washed with saturated sodium sulfate and brine
- concentrationconcentrated
- customto give crude product
출처 및 근거
- ORD 기록
- ord-10c4ca74f28442ce835b3cd9e3e5d290
- 출처 데이터셋
- uspto-grants-2013_10
- 특허 번호
- US08557809B2
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