Benzoyl Peroxide → 1-(Bromomethyl)-2-chloro-3-methylbenzene

HRID 1042347

반응식

HRID 1042347 반응식
[Cl:1][C:2]1[C:7]([CH3:8])=[CH:6][CH:5]=[CH:4][C:3]=1[CH3:9].C1C(=O)N([Br:17])C(=O)C1.C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1>C(Cl)(Cl)(Cl)Cl>[Br:17][CH2:9][C:3]1[CH:4]=[CH:5][CH:6]=[C:7]([CH3:8])[C:2]=1[Cl:1]

참가 물질

5

반응물 3

HCID 7187Benzoyl PeroxideHCID 328851-Chloro-2,6-dimethylbenzeneHCID 67184N-bromobutanimide

생성물 1

HCID 153644661-(Bromomethyl)-2-chloro-3-methylbenzene

시약·촉매·용매 1

HCID 5943Carbon Tetrachloride용매

실험 절차

A solution of 2-chloro-m-xylene (5.00 g, 35.60 mmol), NBS (5.70 g, 32.03 mmol), and a catalytic amount of benzoyl peroxide (100 mg) in CCl4 was refluxed for 1 hour. After cooling to room temperature the resulting mixture was filtered and the filtrate was distilled off. Purification by column chromatography using pentane as the eluant followed by distillation afforded the title compound. Spectroscopic data: 1H NMR (300 MHz, CDCl3.) δ 2.39 (s, 3H), 4.61 (s, 2H), 7.08-7.23 (m, 2H), 7.25-7.30 (m, 1H).

후처리

  1. filtrationwas filtered
  2. distillationthe filtrate was distilled off
  3. customPurification by column chromatography
  4. distillationfollowed by distillation

출처 및 근거

ORD 기록
ord-e569125c88214a4ab8e24fa7f3a77c0e
출처 데이터셋
uspto-grants-2013_10
특허 번호
US08557853B2

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