Sodium Hydroxide → HCID 68649743, 화합물
반응식
C([O:3][C:4](=[O:18])[C:5]1[CH:10]=[CH:9][C:8]([N:11]2[CH2:16][CH2:15][CH:14]([F:17])[CH2:13][CH2:12]2)=[CH:7][CH:6]=1)C.[OH-].[Na+]>C(O)C>[F:17][CH:14]1[CH2:13][CH2:12][N:11]([C:8]2[CH:9]=[CH:10][C:5]([C:4]([OH:18])=[O:3])=[CH:6][CH:7]=2)[CH2:16][CH2:15]1참가 물질
4
실험 절차
A mixture of 4-(4-fluoro-piperidin-1-yl)benzoic acid ethyl ester (0.7 g, 2.7 mmoles) in ethanol (50 ml) and a solution of 2N sodium hydroxide (20 ml) was stirred at room temperature for 24 hours. The ethanol was then evaporated, the solution diluted with water (20 ml) and neutralized with 2N HCl. The acid separated as a white solid which was washed with water and dried under vacuum (0.52 g, 82%).
후처리
- customThe ethanol was then evaporated
- additionthe solution diluted with water (20 ml)
- customThe acid separated as a white solid which
- washwas washed with water
- customdried under vacuum (0.52 g, 82%)
출처 및 근거
- ORD 기록
- ord-35625371840d48a283a25b05f998c074
- 출처 데이터셋
- uspto-grants-2013_10
- 특허 번호
- US08557845B2
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