Lithium Hydroxide → 3-(2-Propyl-4-trifluoromethyl-phenyl)-acrylic acid

HRID 1042470노트

반응식

HRID 1042470 반응식
C[O:2][C:3](=[O:19])[CH:4]=[CH:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]([F:15])([F:14])[F:13])=[CH:8][C:7]=1[CH2:16][CH2:17][CH3:18].[Li+].[OH-]>C1COCC1.O>[CH2:16]([C:7]1[CH:8]=[C:9]([C:12]([F:13])([F:15])[F:14])[CH:10]=[CH:11][C:6]=1[CH:5]=[CH:4][C:3]([OH:19])=[O:2])[CH2:17][CH3:18]

참가 물질

5

반응물 2

HCID 3939Lithium HydroxideHCID 668554943-(2-Propyl-4-trifluoromethyl-phenyl)-acrylic acid methyl ester

생성물 1

HCID 668558853-(2-Propyl-4-trifluoromethyl-phenyl)-acrylic acid수율 74.1%

시약·촉매·용매 2

HCID 962Water용매HCID 8028Tetrahydrofuran용매

실험 절차

To a suspension of 3-(2-propyl-4-trifluoromethyl-phenyl)-acrylic acid methyl ester (220 mg, 0.81 mmol) in THF (3 mL) was added a solution of 1N-LiOH (6 ml), and the mixture was stirred for 3 hours at room temperature. The reaction mixture was diluted with H2O, which was washed three times with EtOAc, acidified with 1N HCl to pH 1-2. The resulting solution was extracted three times with methylene chloride and then dried over anhydrous MgSO4 and concentrated in vacuo to give the title compound (155 mg, 74%).

후처리

  1. washwas washed three times with EtOAc
  2. extractionThe resulting solution was extracted three times with methylene chloride
  3. dry with materialdried over anhydrous MgSO4
  4. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-0412593cba6d4241acb54ea9dce995d6
출처 데이터셋
uspto-grants-2013_10
특허 번호
US08557872B2

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