Cyanuric chloride → Tert-butyl ((2r,5s,7as)-5-cyano-3-oxohexahydropyrrolizin-2-yl)carbamate

HRID 10425

반응식

HRID 10425 반응식
[C:1]([C@@H:4]1[CH2:11][CH2:10][C@@H:9]2[N:5]1[C:6](=[O:20])[C@H:7]([NH:12][C:13](=[O:19])[O:14][C:15]([CH3:18])([CH3:17])[CH3:16])[CH2:8]2)(=O)[NH2:2].N1C(Cl)=NC(Cl)=NC=1Cl>CN(C)C=O>[C:1]([C@@H:4]1[CH2:11][CH2:10][C@@H:9]2[N:5]1[C:6](=[O:20])[C@H:7]([NH:12][C:13](=[O:19])[O:14][C:15]([CH3:16])([CH3:17])[CH3:18])[CH2:8]2)#[N:2]

참가 물질

4

반응물 2

HCID 7954Cyanuric chlorideHCID 90895673HCID 90895673, 화합물

생성물 1

HCID 91321587Tert-butyl ((2r,5s,7as)-5-cyano-3-oxohexahydropyrrolizin-2-yl)carbamate

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

100 mg of tert-butyl ((2R,5S,7aS)-5-carbamoyl-3-oxohexahydropyrrolizin-2-yl)carbamate were dissolved in 2 ml of dimethylformamide, and 65 mg of cyanuric chloride were added. The mixture was stirred for 3 h, and the dimethylformamide was removed in vacuo. The residue was chromatographed on silica gel.

후처리

  1. customthe dimethylformamide was removed in vacuo
  2. customThe residue was chromatographed on silica gel

출처 및 근거

ORD 기록
ord-93eff2bf0daa450c897e724582f37625
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07094800B2

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