Trimethylsilylacetylene → 1-benzyl-4-ethynyl-1H-pyrazole

HRID 1042563노트

반응식

HRID 1042563 반응식
C(N1C=C(I)C=N1)C1C=CC=CC=1.[C:14]([C:16]1[CH:17]=[N:18][N:19]([CH2:21][C:22]2[CH:27]=[CH:26][C:25](OC)=[CH:24][CH:23]=2)[CH:20]=1)#[CH:15].C[Si](C#C)(C)C>>[CH2:21]([N:19]1[CH:20]=[C:16]([C:14]#[CH:15])[CH:17]=[N:18]1)[C:22]1[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=1

참가 물질

4

반응물 3

HCID 66111TrimethylsilylacetyleneHCID 37945791-Benzyl-4-iodo-1H-pyrazoleHCID 574219374-Ethynyl-1-(4-methoxybenzyl)-1H-pyrazole

생성물 1

HCID 574219391-benzyl-4-ethynyl-1H-pyrazole수율 83%

실험 절차

This compound was prepared from 1-benzyl-4-iodo-1H-pyrazole using a similar procedure to that employed in the preparation of 4-ethynyl-1-(4-methoxy-benzyl)-1H-pyrazole (see a)(ii) above). The reaction time was extended to 5 h and 1.6 equivalents of trimethylsilylacetylene were added. Silica-gel flash chromatography of the crude reaction mixture afforded the product as a white solid (83% yield over two steps).

후처리

  1. customSilica-gel flash chromatography of the crude reaction mixture

출처 및 근거

ORD 기록
ord-5627b99511164e6db8bfc80cb2481444
출처 데이터셋
uspto-grants-2013_10
특허 번호
US08557982B2

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