3-Hydroxybenzaldehyde → 3-(Dimethylaminomethyl)phenol

HRID 1043059

반응식

HRID 1043059 반응식
[OH:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][CH:9]=1)[CH:5]=O.[CH3:10][NH:11][CH3:12].C(O[BH-](OC(=O)C)OC(=O)C)(=O)C.[Na+].CO>C1COCC1.C(Cl)Cl>[CH3:10][N:11]([CH2:5][C:4]1[CH:3]=[C:2]([OH:1])[CH:9]=[CH:8][CH:7]=1)[CH3:12]

참가 물질

7

반응물 4

HCID 1013-HydroxybenzaldehydeHCID 674DimethylamineHCID 887MethanolHCID 5049666Sodium triacetoxyborohydride

생성물 1

HCID 328963-(Dimethylaminomethyl)phenol

시약·촉매·용매 2

HCID 6344Dichloromethane용매HCID 8028Tetrahydrofuran용매

실험 절차

3-Hydroxybenzaldehyde (1.0 g), 2M dimethylamine in THF (5 mL), and sodium triacetoxyborohydride (2 g) in CH2Cl2 (10 mL) were stirred for 24 hours. The mixture was treated with methanol and chromatographed on silica gel with 2-25% ethyl acetate/hexanes.

후처리

  1. customchromatographed on silica gel with 2-25% ethyl acetate/hexanes

출처 및 근거

ORD 기록
ord-a87bbf9c63684d14a3aff343df0d7a24
출처 데이터셋
uspto-grants-2013_10
특허 번호
US08557983B2

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